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THE FUTURE OF ENGINEERED TISSUE
Phase 1 Winner

NIH Complement-ARIE NAMs Challenge

A Living Vascular Graft

A living graft made from the patient's own cells, seeded and implanted in the same surgery.
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Regenerate

The patient's cells build new tissue as the scaffold dissolves, leaving a living vessel.
implant_vessel_noholes_2026-09-29.jpg

Implant

The surgeon attaches it like any other graft, in the same operation.
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Seed

Our scaffold, plus the patient's own cells from a small fat sample.
Presto_explant_blue_brightened_20250613_CD31(2)_10x 2_rgb_CH(Cy3)_CH2.jpg

Implanted in a Large Animal

Living Lining by Day 14

Living Lining by Day 14

Traditional grafts never grow it
Traditional grafts never grow it

No clotting, no adverse effects. Traditional grafts clot fast in similar studies.

No clotting, no adverse effects. Traditional grafts clot fast in similar studies.

14 DAYS.

A living lining formed on the graft in just 14 days in our first large animal study.

Traditional grafts never form a living lining.

Presto_explant_blue_brightened_20250613_CD31(2)_10x 2_rgb_CH(Cy3)_CH2.jpg

No clotting, no adverse effects. Traditional grafts clot fast in similar studies.

No clotting, no adverse effects. Traditional grafts clot fast in similar studies.

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The 2 options surgeons have today

Synthetic Grafts
High risk of clotting.

Up to

0%

failure rate within
2 years

Pashneh-Tala et al., Tissue Eng Part B, 2016, Fig. 1.

The patient's own vein (Gold Standard)
Works, but adds hours and a second wound.

~

0%

of leg-bypass patients have
no ideal vein to spare

McGevna et al,. Annals of Vascular Surgery, 2026

A graft that works could help ~750,000 patients in the US every year.

operating theater
Frontier Bio Logo.png

Creating replacement blood vessels.

SEED. IMPLANT. REGENERATE

SUPPORTED BY

StartX
Intuitive Surgical
Mayo Clinic
Duke University
NSF
MTEC
ARMI
SBIR
Eleven Labs
Leap
Berkeley Skydeck
Brinc
HealthSpan Action
Alchemist
Health Engine
Levita
National University of Singapore
Nvidia Inception Program
Stanford University

Backed By

Our investors include founders and CEOs, senior executives at $100B+ companies, and a Nobel laureate.
Portfolia
Immortal Dragons
Infinita VC
100 Plus Capital
Mistletoe
Artesian VC
Hatcher+
Asymmetry Ventures
Break Off Capital
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