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Neural Microtissues

Re-thinking the future of drug discovery and disease modeling

Recapitulating the brain in the lab is no easy task, especially since it involves complex vasculature and the Blood-Brain Barrier (BBB). Frontier Bio can reproduce these complexities.

Neurosphere Axons

Chip Format

NeuroTraX™: Blood-Brain-Barrier Chip

The Neuro-Vascular-Unit (NVU) is the building block of the brain made of neurons, endothelial cells, astrocytes, pericytes, and microglia. NeuroTraX creates the NVU in an easy-to-use, easy-to-image format, featuring a continuous Blood-Brain-Barrier (BBB) unlike other chips that require posts or membranes that disrupt tissue continuity. 

Sphere Format

NeuroDots™: Vascularized Neurospheres

Our NeuroDots™ can be used for applications such as drug screening, toxicity screening, and even bio-hybrid computation / intelligence.  NeuroDots™ are created with human cells and can save precious time and resources in drug development. Vascularization allows delivery of oxygen and nutrients to the entire tissue, enhancing tissue function and improving translational value.

NeuroDots: Vascularized Neural Spheroids (NeuroSpheres) in a Dish

We can help answer your questions pertaining to:
 

  • Drug Transport (Can our drug cross the BBB?)

  • Neurological Effects (How does our drug affect the brain?)

  • Drug Toxicity (Is our drug toxic to the brain or BBB?)

  • Drug Efficacy (Does our drug improve the features of a neurological disease?)

  • Disease Modeling (What are the mechanisms of disease?)

NVU Microfluidic BBB Chip, Brain-on-a-Chip

EXAMPLES

Breast Cancer Metastasis On-Chip
Breast Cancer Metastasis On-Chip

CANCER METASTASIS

This figure shows NeuroTraX™ BBB cell-selectivity as a model for cancer metastasis. MB-231Br, a brain-seeking cancer line, extensively invades the NVU as compared to the wild-type MB-231 which does not cross the BBB. 

ISCHAEMIC STROKE

Ischaemic Stroke On-Chip

NeuroTraX™ could be used to monitor several disease states. The figure above shows its application in ischaemic stroke modeling. Other diseases applications include traumatic brain injuries, Alzheimer's disease, viral infection, and mutation-specific familial diseases among others.

STEM CELL THERAPY

Stem Cell Therapy  On-Chip

NeuroTraX™ BBB cell-selectivity screens for effectiveness of cell-based therapies and screen non-BBB-crossing cell therapies out of the pipeline.

Reach out to explore collaboration & partnership possibilities

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